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Dr Luke Geever

Post-doctoral Researcher

Luke Geever graduated from Athlone Institute of Technology (AIT) in 2004 with an Honours Degree in Polymer Science, having previously attained a National Certificate and National Diploma in Plastics Engineering. He recently completed his PhD studies under the joint supervision of Dr. Clement Higginbotham and Dr. Michael Nugent. His PhD thesis centred on the development of ‘smart’ negative temperature sensitive polymeric materials for potential biomedical applications, and involved use of a wide range of highly sophisticated analytical techniques. To date, he had 11 peer-reviewed paper articles accepted (6 on his PhD studies and 5 in related disciplines), which have been published in journals such as the European Polymer Journal, Journal of Materials Science and the European Journal of Pharmaceutics and Biopharmaceutics. Also, he has participated at a number of recent biomedical conferences, most notably presenting oral presentations at the 21st European Conference on Biomaterials and the International Conference on Biohydrogels in 2007. In addition, he has carried out a multitude of other responsibilities, ranging from analytical testing to literature searches in diverse research project areas (i.e., development of lubricious hydrophilic coatings for cardio vascular stents, evaluation and production of biodegradable polymers, and development and analysis of novel compostable biopolymers), working in conjunction with companies including Clearstream Technologies Ltd., Holfeld Plastics Ltd., Biobode Ltd and Waveware Ltd.

List of Publications

Journal Publications

James E. Kennedy, Declan M. Devine, John G. Lyons, Luke M. Geever, Clement L. Higginbotham (2009) The synthesis and characterisation of grafted random styrene butadiene for biomedical applications Journal of Materials Science, In Press, DOI: 10.1007/s10853-008-3156-2

Luke M. Geever, Ciaran C. Cooney, John G. Lyons, James E. Kennedy, Michael J.D. Nugent, Sinead Devery, Clement L. Higginbotham (2008)Characterisation and controlled drug release from novel drug-loaded hydrogelsEuropean Journal of Pharmaceutics and Biopharmaceutics, 69 (3), 1147-1159

Lyons, J.G., Devine, D.M., Kennedy, J.E., Geever, L.M., O’ Sullivan, P. & Higginbotham, C.L., 2007, ‘The use of Agar as a novel filler for monolithic matrices produced from hot melt extrusion’.European Journal of Pharmaceutics and Biopharmaceutics, 64, 1, 75-81

Geever, L.M., Mínguez, C.M., Devine, D.M., Nugent, M.J.D., Kennedy, J.E., Lyons, J.G., Hanley, A., Devery, S., Tomkins, P.T., Higginbotham, C.L., 2007, ‘The synthesis, swelling behaviour and rheological properties of chemically crosslinked thermosensitive copolymers based on N-isopropylacrylamide’. Journal of Materials Science, 42, 4136-4148

Lyons, J.G., Holehonnur, H., Devine, D.M., Kennedy, J.E., Geever, L.M., Blackie, P. & Higginbotham, C.L., 2007, ‘The incorporation of an organically modified layered silicate in monolithic polymeric matrices produced using hot melt extrusion’.Materials Chemistry and Science, 103, 419-426

Lyons, J.G., Hallinan, M., Kennedy, J.E., Devine, D.M., Geever, L.M., Blackie, P. & Higginbotham, C.L., 2007, ‘Preparation of monolithic matrices for oral drug delivery using a supercritical fluid assisted hot melt extrusion process’.International Journal of Pharmaceutics, 329, 62-71

Geever, L.M., Nugent, M.J.D., Higginbotham, C.L., 2007, ‘The effect of salts and pH buffer solutions on the phase transition temperature and swelling of thermoresponsive pseudogels based on N-isopropylacrylamide’. Journal of Materials Science, 42, 9845-9854

Geever, L.M., Devine, D.M., Nugent, M.J.D., Kennedy, J.E., Lyons, J.G., Higginbotham, C.L., 2006, ‘The synthesis, characterisation, phase behaviour and swelling of temperature sensitive physically crosslinked poly(1-vinyl-2-pyrrolidinone)/poly(N-isopropylacrylamide) hydrogels’. European Polymer Journal, 42, 69-80

Devine, D.M., Devery, S.M., Lyons, J.G., Geever, L.M., Kennedy, J.E., Higginbotham, C.L., 2006, ‘Multifunctional polyvinylpyrrolidinone-polyacrylic acid copolymer hydrogels for biomedical applications’.International Journal of Pharmaceutics, 326, 50-59

Geever, L.M., Devine, D.M., Nugent, M.J.D., Kennedy, J.E., Lyons, J.G., Hanley, A., Higginbotham, C.L., 2006, ‘Lower critical solution temperature control and swelling behaviour of physically crosslinked thermosensitive copolymers based on N-isopropylacrylamide’. European Polymer Journal, 42, 2540-2548

Devine, D.M., Geever, L.M., Higginbotham, C.L., 2005, Drug release from a N-vinylpyrrolidinone/Acrylic Acid lubricious hydrophilic coatingJournal of Materials Science, 40, 3429-3436

Geever, L.M., Cooney, C.C., Lyons, J.G., Kennedy, J.E., Nugent, M.J.D., Devery, S., Higginbotham, C.L., In Press, Accepted Manuscript, ‘Characterisation and controlled drug release from novel drug-loaded hydrogels’.European Journal of Pharmaceutics and Biopharmaceutics, In Press, Accepted Manuscript.

Geever, L.M., Cooney, C.C., Devine, D.M., Devery, S., Nugent, M.J.D., Higginbotham, C.L., In Press, Accepted Manuscript, ‘Negative Temperature Sensitive Hydrogels in Controlled Drug Delivery’. Macromolecular Symposia, In Press, Accepted Manuscript.

Conference Publications

Geever, L.M., Nugent, M.J.D., Higginbotham, C.L., (2008). ‘Thermo Responsive Hydrogels’,INSTITUTE OF CHEMISTRY IRELAND ANNUAL CONFERENCE -NANOTECHNOLOGY, May 16th 2008, Athlone (IRELAND).

Devine, D.M., Geever, L.M., Higginbotham, C.L., (2007). ‘Development of Hydrogels for Moist Wound Healing’,7th INTERNATIONAL SYMPOSIUM ON FRONTIERS IN BIOMEDICAL POLYMERS (FBPS 07), June 24-27th 2007, Het Pand, Ghent (BELGIUM).

Geever, L.M., Cooney, C., Devine, D.M., Devery, S., Nugent, M.J.D., Higginbotham, C.L., (2007). ‘Negative Temperature Sensitive Hydrogels in Controlled Drug Delivery’,INTERNATIONAL CONGRESS ON BIOHYDROGELS, November 14-17th 2007, Congress Centre “Principe di Piemonte”, Viareggio (ITALY).

Geever, L.M., Devine, D.M., Nugent, M.J.D., Higginbotham, C.L., (2007). ‘Temperature Sensitive Poly(N-isopropylacrylamide) Based Gels for Controlled Drug Delivery’,21st EUROPEAN CONFERENCE ON BIOMATERIALS, September 9-13th 2007, Brighton (UK).

Cooney, C., Geever, L.M., Devery, S., Higginbotham, C.L., (2007). ‘Biocompatibility of Nanoporous N-isopropylacrylamide - (1-vinyl-2-pyrrolidinone) Copolymer Hydrogels’,IRISH SOCIETY OF TOXICOLOGY, NANOTECHNOLOGY, November 02nd 2007, Dublin (IRELAND).

Devine, D.M., Lyons, J.G., Geever, L.M., Higginbotham, C.L., (2007). ‘Site-specific delivery of aspirin to the small intestine’, 21st EUROPEAN CONFERENCE ON BIOMATERIALS, September 09-13th 2007, Brighton (UK).

Cooney, C., Geever, L.M., Devery, S., Higginbotham, C.L., (2007). ‘Cytocompatibility of (1-vinyl-2-pyrrolidinone) based hydrogels’,21st EUROPEAN CONFERENCE ON BIOMATERIALS, September 09-13th 2007, Brighton (UK).

Geever, L.M., Devine, D.M., Nugent, M.J.D., Higginbotham, C.L., (2007). ‘Controlled drug delivery using negative temperature sensitive hydrogels’,7th INTERNATIONAL SYMPOSIUM ON FRONTIERS IN BIOMEDICAL POLYMERS (FBPS 07), June 24-27th 2007, Het Pand, Ghent (BELGIUM).

Geever, L.M., Devine, D.M., Nugent, M.J.D., Higginbotham, C.L., (2006). ‘Controlled Erosion of Physically Crosslinked Hydrogels for Temperature Dependent Drug Release’,1st INTERNATIONAL CONFERENCE ON MATERIALS ENERGY AND DESIGN, March 14-17th 2006, Dublin Institute of Technology, Bolton Street, Dublin (IRELAND).

Geever, L.M., Devine, D.M., Kennedy, J.E., Devery, S., Lawlor, O., Higginbotham, C.L., (2006). ‘Chemically crosslinked temperature sensitive hydrogels for controlled release drug delivery’,20th EUROPEAN CONFERENCE ON BIOMATERIALS, September 27th - October 1st 2006, Cite des Congres, Nantes (FRANCE).

Devine, D.M., Geever, L.M., Devery, S., Lawlor, O., Higginbotham, C.L., (2006). ‘Synthesis and characterisation of hydrophilic polymers and their role in drug delivery’,20th EUROPEAN CONFERENCE ON BIOMATERIALS, September 27th - October 1st 2006, Cite des Congres, Nantes (FRANCE).

Devine, D.M., Geever, L.M., Devery, S., Higginbotham, C.L., (2006). ‘In situ UV polymerisation of a lubricious hydrophilic coating’,INTERNATIONAL CONFERENCE ON ADVANCES IN BIOMATERIALS FOR DRUG DELIVERY AND REGENERATIVE MEDICINE, 11-16th June 2006, Hotel La Residenza, Capri (ITALY).

Geever, L.M., Devine, D.M., Devery, S., Lawlor, O., Higginbotham, C.L., (2006). ‘Chemically crosslinked temperature sensitive hydrogels for site specific drug delivery’,INTERNATIONAL CONFERENCE ON ADVANCES IN BIOMATERIALS FOR DRUG DELIVERY AND REGENERATIVE MEDICINE, 11-16th June 2006, Hotel La Residenza, Capri (ITALY).

Devine, D.M., Geever, L.M., Devery, S., Higginbotham, C.L., (2006). ‘The drug release and cytotoxicity response of hydrogels with potential for wound healing applications’,MATERIALS CONGRESS, April 5-7th 2006, Carlton House Terrace, London (UK).

Geever, L.M., Devine, D.M., Nugent, M.J.D., Higginbotham, C.L., (2006).‘The synthesis, characterisation and drug release profile of temperature sensitive physically crosslinked N-isopropylacrylamide based hydrogels’,MATERIALS CONGRESS, April 5-7th 2006, Carlton House Terrace, London (UK).

Devine, D.M., Geever, L.M., Devery, S., Higginbotham, C.L., (2006). ‘In situ UV polymerisation of a lubricious polymer with potential for use as a medical device coating’,1st INTERNATIONAL CONFERENCE ON MATERIALS ENERGY AND DESIGN, March 14-17th 2006, Dublin Institute of Technology, Bolton Street, Dublin (IRELAND).

Devine, D.M., Geever, L.M., Higginbotham, C.L., (2006). ‘Lubricious hydrophilic polymers for medical applications’,3rd ANNUAL BIONET CONFERENCE, January 18-19th 2006, Institute of Technology Tallaght, Dublin (IRELAND).

Geever, L.M., Devine, D.M., Nugent, M.J.D., Higginbotham, C.L., (2005). ‘Physically crosslinked temperature sensitive hydrogels for controlled release drug delivery’19th EUROPEAN CONFERENCE ON BIOMATERIALS, September 11-15th 2005, Sorrento Palace Hotel, Sorrento (ITALY).

Devine, D.M., Geever, L.M., Higginbotham, C.L., (2005). ‘Lubricious hydrophilic polymers for drug delivery applications’,19th EUROPEAN CONFERENCE ON BIOMATERIALS, September 11-15th 2005, Sorrento Palace Hotel, Sorrento (ITALY).

Devine, D.M., Geever, L.M., Coubrun, O., Higginbotham, C.L., (2005). ‘The synthesis and characterisation of a N-vinyl pyrrolidinone/acrylic acid copolymer for drug delivery applications’,CONFERENCE ON DRUG DELIVERY AND DIFFUSION THROUGH POLYMERS, June 21st 2005, Institute of Physics, London (UK).

Geever, L.M., Devine, D.M., Nugent, M.J.D., Higginbotham, C.L., (2005). ‘The synthesis, characterisation and thermoreversible gelation of temperature sensitive physically crosslinked N-isopropylacrylamide based copolymers’,CONFERENCE ON DRUG DELIVERY AND DIFFUSION THROUGH POLYMERS, June 21st 2005, Institute of Physics, London (UK).

Geever, L.M., Devine, D.M., Nugent, M.J.D., Higginbotham, C.L., (2004). ‘The synthesis, characterisation and swelling of temperature sensitive physically crosslinked N-isopropylacrylamide hydrogel copolymers’,10th INTERNATIONAL CONFERENCE ON POLYMERS IN MEDICINE AND SURGERY, September 6-8th 2004, Robinson College, Cambridge (UK).

Devine, D.M., Geever, L.M., Higginbotham, C.L., (2004). ‘The synthesis and characterisation of crosslinked NVP/AA copolymers for medical applications’,10th INTERNATIONAL CONFERENCE ON POLYMERS IN MEDICINE AND SURGERY, September 6-8th 2004, Robinson College, Cambridge (UK).

Devine, D.M., Geever, L.M., Higginbotham, C.L., (2004).‘The synthesis, characterisation and testing of a chemically cross-linked NVP/AA based copolymer for drug delivery applications’,MATERIALS CONGRESS, March 30th - April 1st 2004, London (UK).

Geever, L.M., Devine, D.M., Nugent, M.J.D., Higginbotham, C.L., (2004).‘Synthesis, characterisation and swelling studies of a temperature sensitive NVP based copolymer for drug delivery applications’,MATERIALS CONGRESS, March 30th - April 1st 2004, London (UK).

Higginbotham, C.L., Devine, D.M., Geever, L.M., Kennedy, J.E., McDonald, P.F., Lyons, J.G., Nugent, M.J.D., (2004). ‘Characterisation of polymer systems for drug delivery applications’,NANOFABRICATIONS SYMPOSIUM, March 10-12th 2004, Dundalk (IRELAND).

Higginbotham, C.L., Devine, D.M., Geever, L.M., Kennedy, J.E., McDonald, P.F., Lyons, J.G., Nugent, M.J.D., (2004). ‘Investigation of Polymer Systems for Biomedical Applications’, NANOFABRICATIONS SYMPOSIUM, March 10-12th 2004, Dundalk (IRELAND).

Devine, D.M., Geever, L.M., Higginbotham, C.L., (2004). ‘Drug Release from Novel NVP/AA Copolymer Coatings for Reduced Friction Applications’10th INTERNATIONAL CONFERENCE ON POLYMERS IN MEDICINE AND SURGERY, September 6-8th 2004, Robinson College, Cambridge (UK).